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Total 109493 results found since Jan 2013.

Novel Lesional Transcriptional Signature Separates Atherosclerosis With and Without Diabetes in Yorkshire Swine and Humans.
CONCLUSIONS: This study identifies evolutionarily conserved gene signatures and signaling pathways in a stage-specific manner that successfully distinguishes diabetes- and non-diabetes-associated atherosclerosis. These findings establish new molecular insights and therapeutic opportunities to address accelerated atherosclerotic lesion formation in diabetes. PMID: 33567868 [PubMed - as supplied by publisher]
Source: Arteriosclerosis, Thrombosis and Vascular Biology - February 11, 2021 Category: Cardiology Authors: Haemmig S, Hashemi Gheinani A, Zaromytidou M, Siasos G, Coskun AU, Cormier MA, Gross DA, Wara AKMK, Antoniadis A, Sun X, Sukhova GK, Welt F, Andreou I, Whatling C, Gan LM, Wikström J, Edelman ER, Libby P, Stone PH, Feinberg MW Tags: Arterioscler Thromb Vasc Biol Source Type: research

Ultrasound‐Targeted Microbubble Destruction Enhances Gene Expression of microRNA‐21 in Swine Heart via Intracoronary Delivery
ConclusionUnder suitable conditions, UTMD can efficiently enhance gene expression in swine heart regardless of the delivery routes. The intravenous injection might be superior to intracoronary injection with less invasiveness and lower requirement of the technique. And for those undergoing percutanesous coronary intervention, intracoronary injection seems to be another alternative.
Source: Echocardiography - January 1, 2015 Category: Cardiology Authors: Yangchun Liu, Lang Li, Qiang Su, Tao Liu, Zhiying Ma, Huafeng Yang Tags: Original Investigation Source Type: research

Ventricular fibrillation: are swine a sensitive species?
Conclusions Swine are about three times as sensitive to the electrical induction of VF as are humans.
Source: Journal of Interventional Cardiac Electrophysiology - January 16, 2015 Category: Cardiology Source Type: research

Impaired pulmonary vasomotor control in exercising swine with multiple comorbidities
In conclusion, common comorbidities directly alter pulmonary vascular control, by enhanced PDE5 and endothelin-mediated vasoconstrictor influences, well before overt left ventricular backward failure or pulmonary hypertension develop.
Source: Basic Research in Cardiology - September 12, 2021 Category: Cardiology Source Type: research

Chronic high-rate pacing induces heart failure with preserved ejection fraction-like phenotype in Ossabaw swine
We examined whether chronic cardiometabolic stress in Ossabaw swine, which possess a genetic propensity for obesity and cardiovascular complications, produces an HFpEF-like phenotype. Swine were fed standard chow (lean;n = 13) or an excess calorie, high-fat, high-fructose diet (obese;n = 16) for ~ 18 weeks with lean (n = 5) and obese (n = 8) swine subjected to right ventricular pacing (180 beats/min for ~ 4 weeks) to induce heart failure (HF). Baseline blood pressure, heart rate, LV end-diastolic volume, and ejection fraction were similar between groups. High-rate pacing increased LV end-diastolic...
Source: Basic Research in Cardiology - October 12, 2022 Category: Cardiology Source Type: research

Plaque burden is associated with minimal intimal coverage following drug-eluting stent implantation in an adult familial hypercholesterolemia swine model
Sci Rep. 2023 Jul 1;13(1):10683. doi: 10.1038/s41598-023-37690-0.ABSTRACTSafety and efficacy of coronary drug-eluting stents (DES) are often preclinically tested using healthy or minimally diseased swine. These generally show significant fibrotic neointima at follow-up, while in patients, incomplete healing is often observed. The aim of this study was to investigate neointima responses to DES in swine with significant coronary atherosclerosis. Adult familial hypercholesterolemic swine (n = 6) received a high fat diet to develop atherosclerosis. Serial OCT was performed before, directly after, and 28 days after DES implanta...
Source: Atherosclerosis - July 1, 2023 Category: Cardiology Authors: Francesca Razzi Jouke Dijkstra Ayla Hoogendoorn Karen Witberg Jurgen Ligthart Dirk J Duncker Jan van Esch Jolanda J Wentzel Volkert van Steijn Gijs van Soest Evelyn Regar Heleen M M van Beusekom Source Type: research

Development of Aortic Valve Disease in Familial Hypercholesterolemic Swine: Implications for Elucidating Disease Etiology Valvular Heart Disease
Conclusions Adult RFH swine exhibited several hallmarks of early human CAVD, suggesting potential for these animals to help elucidate CAVD etiology in both FH and non-FH individuals. The development of advanced atherosclerotic lesions, but only early-stage CAVD, in RFH swine supports the hypothesis of an initial shared disease process, with additional stimulation necessary for further progression of CAVD.
Source: JAHA:Journal of the American Heart Association - October 27, 2015 Category: Cardiology Authors: Porras, A. M., Shanmuganayagam, D., Meudt, J. J., Krueger, C. G., Hacker, T. A., Rahko, P. S., Reed, J. D., Masters, K. S. Tags: Valvular Heart Disease Source Type: research

Comparing the incidence of ventricular arrhythmias during epicardial ablation in swine vs. canine models
Conclusions: The swine myocardium is more susceptible to developing ventricular arrhythmias compared to canine model during epicardial ablation. This issue should be carefully considered in future studies.This article is protected by copyright. All rights reserved
Source: Pacing and Clinical Electrophysiology : PACE - April 14, 2019 Category: Cardiology Authors: Guido Caluori, Adam Wojtaszczyk, Omar Yasin, Martin Pesl, Ji ří Wolf, Silvie Belaskova, Michal Crha, Alan Sugrue, Vaibhav R. Vaidya, Niyada Naksuk, Christopher V. DeSimone, Ammar M. Killu, Deepak Padmanabhan, Samuel J. Asirvatham, Zdeněk Tags: ELECTROPHYSIOLOGY Source Type: research

Comparing the incidence of ventricular arrhythmias during epicardial ablation in swine versus canine models
ConclusionsThe swine myocardium is more susceptible to developing ventricular arrhythmias compared to canine model during epicardial ablation. This issue should be carefully considered in future studies.
Source: Pacing and Clinical Electrophysiology : PACE - April 28, 2019 Category: Cardiology Authors: Guido Caluori, Adam Wojtaszczyk, Omar Yasin, Martin Pesl, Ji ří Wolf, Silvie Belaskova, Michal Crha, Alan Sugrue, Vaibhav R. Vaidya, Niyada Naksuk, Christopher V. DeSimone, Ammar M. Killu, Deepak Padmanabhan, Samuel J. Asirvatham, Zdeněk Tags: ELECTROPHYSIOLOGY Source Type: research

Effects of Metabolic Syndrome and SIRT1 Mutation on Store-Operated Ca < sup > 2+ < /sup > Entry in Peripheral Blood Mononuclear Cells in Ossabaw Miniature Swine
CONCLUSION: SIRT1L100P mutation is likely to require longer duration to manifest robust effects on PBMC SOCE that were found with MetS diet. PBMC activation and can be easily studied longitudinally in the SIRT1L100P mutant swine model due to the ease of blood sampling.PMID:35553311 | DOI:10.1096/fasebj.2022.36.S1.R6354
Source: Atherosclerosis - May 13, 2022 Category: Cardiology Authors: Aish Thamba Chris Royer Jason Collett James Byrd Mouhamad Alloosh Alex Coutts David Basile Michael Sturek Source Type: research

A novel polymer-free everolimus-eluting stent with a nitrogen-doped titanium dioxide film inhibits restenosis and thrombosis in a swine coronary model
CONCLUSIONS: The novel polymer-free EES with an N-TiO₂ film has superior safety and efficacy than the polymer-free SES at the 6-month follow-up in a swine model.PMID:36790043 | DOI:10.5603/CJ.a2023.0006
Source: Cardiology Journal - February 15, 2023 Category: Cardiology Authors: Dae Young Hyun Xiongyi Han Dae Sung Park Munki Kim Jun Kyu Park Kyung Hoon Cho Doo Sun Sim Young Joon Hong Youngkeun Ahn Myung Ho Jeong Source Type: research